Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila

被引：88

作者：

Zeng, Xiankun ^{[1
]}

Sun, Mingkuan ^{[1
]}

Liu, Li ^{[1
]}

Chen, Fading ^{[1
]}

Wei, Liuchan ^{[1
]}

Xie, Wei ^{[1
]}

机构：

[1] SE Univ, Sch Med, Dept Genet & Dev Biol,Minist Educ, Genet Res Ctr,Key Lab Dev Genes & Human Dis, Nanjing 210009, Jiangsu Prov, Peoples R China

来源：

FEBS LETTERS | 2007年 / 581卷 / 13期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.febslet.2007.04.068

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurexins are highly polymorphic cell-surface adhesive molecules in neurons. In cultured mammalian cell system, they were found to be involved in synaptogenesis. Here, we report for the first time that Drosophila neurexin is required for synapse formation and associative learning in larvae. Drosophila genome encodes a single functional neurexin (CG7050; Neurexin-1 or Nrx-1), which is a homolog of vertebrate a-neurexin. Neurexin-1 is expressed in central nervous system and highly enriched in synaptic regions of the ventral ganglion and brain. Neurexin-1 null mutants are viable and fertile, but have shortened lifespan. The synapse number is decreased in central nervous system in Neurexin-1 null mutants. In addition, Neurexin-1 null mutants exhibit associative learning defect in larvae. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2509 / 2516

页数：8

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