Piscicidal properties of piperovatine from Piper piscatorum (Piperaceae)

被引：26

作者：

McFerren, MA ^{[1
]}

Rodriguez, E ^{[1
]}

机构：

[1] Cornell Univ, Div Biol Sci, LH Bailey Hortorium, Ithaca, NY 14853 USA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1998年 / 60卷 / 02期

关键词：

Piper piscatorum; Piperaceae; isobutylamides; piperovatine; pipercallosidine; piscicidal; sialagogic;

D O I：

10.1016/S0378-8741(97)00154-2

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Extraction of the roots of the Amazonian medicinal plant, Piper piscatorum Trelease and Yuncker, with MeOH and subsequent bioassay guided fractionation using the guppy, Girardina guppii; yielded the active amide, N-isobutyl-6-(p-methoxyphenyl) 2E, 4E-hexadieneamide (piperovatine) and a second inactive amide, N-isobutyl-(E)-7-(3,4-methylene-dioxyphenyl)hept-2-enamide (pipercallosidine). The former displayed an LC50 of 115 ng/ml in toxicity tests and proved to be the constituent responsible for the dual ethnobotanical uses of this plant: that of fish stupefacient (barbasco) and oral local anesthetic. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：183 / 187

页数：5

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