Time-dependent sensitization - possible implications for clinical psychopharmacology

被引:29
作者
Antelman, SM [1 ]
Soares, JC [1 ]
Gershon, S [1 ]
机构
[1] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA
来源
BEHAVIOURAL PHARMACOLOGY | 1997年 / 8卷 / 6-7期
关键词
antidepressants; mechanisms of action; neuropharmacology; psychopharmacology; psychotropic agents; therapeutics; time-dependent sensitization;
D O I
10.1097/00008877-199711000-00006
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Time-dependent sensitization (TDS) has been described in animal models over the past 20 years. It is a phenomenon that occurs in a variety of biological systems, and corresponds to the cellular and systems response to a foreign or stressful stimulus. The exposure to the stimulus triggers the responses typical of that particular biological system, which are progressively amplified with time. This phenomenon has potential major implications for clinical pharmacology. Some human studies have investigated this phenomenon to date. Antidepressant action, with its typical lag in the onset of effects, may be a fruitful paradigm to understand the relevance of TDS for psychopharmacological treatment. In this paper we review these emerging findings, and suggest that clinical pharmacology research should investigate this process further in expanded human studies.
引用
收藏
页码:505 / 514
页数:10
相关论文
共 62 条
  • [1] Anteinaan S. M., 1983, STIMULANTS NEUROCHEM, P269
  • [2] ONE EXPERIENCE WITH LOWER OR HIGHER INTENSITY STRESSORS, RESPECTIVELY ENHANCES OR DIMINISHES RESPONSIVENESS TO HALOPERIDOL WEEKS LATER - IMPLICATIONS FOR UNDERSTANDING DRUG VARIABILITY
    ANTELMAN, SM
    CAGGIULA, AR
    KOCAN, D
    KNOPF, S
    MEYER, D
    EDWARDS, DJ
    BARRY, H
    [J]. BRAIN RESEARCH, 1991, 566 (1-2) : 276 - 283
  • [3] AMITRIPTYLINE SENSITIZATION OF A SEROTONIN-MEDIATED BEHAVIOR DEPENDS ON THE PASSAGE OF TIME AND NOT REPEATED TREATMENT
    ANTELMAN, SM
    DEGIOVANNI, LA
    KOCAN, D
    PEREL, JM
    CHIODO, LA
    [J]. LIFE SCIENCES, 1983, 33 (17) : 1727 - 1730
  • [4] Oscillation follows drug sensitization: Implications
    Antelman, SM
    Caggiula, AR
    [J]. CRITICAL REVIEWS IN NEUROBIOLOGY, 1996, 10 (01): : 101 - 117
  • [5] TIME-DEPENDENT SENSITIZATION AS THE CORNERSTONE FOR A NEW APPROACH TO PHARMACOTHERAPY - DRUGS AS FOREIGN STRESSFUL STIMULI
    ANTELMAN, SM
    [J]. DRUG DEVELOPMENT RESEARCH, 1988, 14 (01) : 1 - 30
  • [6] AMPHETAMINE OR HALOPERIDOL 2 WEEKS EARLIER ANTAGONIZED THE PLASMA-CORTICOSTERONE RESPONSE TO AMPHETAMINE - EVIDENCE FOR THE STRESSFUL FOREIGN NATURE OF DRUGS
    ANTELMAN, SM
    CAGGIULA, AR
    KNOPF, S
    KOCAN, DJ
    EDWARDS, DJ
    [J]. PSYCHOPHARMACOLOGY, 1992, 107 (2-3) : 331 - 336
  • [7] ANTELMAN SM, 1994, TOXICOL IND HEALTH, V10, P335
  • [8] INTERCHANGEABILITY OF STRESS AND AMPHETAMINE IN SENSITIZATION
    ANTELMAN, SM
    EICHLER, AJ
    BLACK, CA
    KOCAN, D
    [J]. SCIENCE, 1980, 207 (4428) : 329 - 331
  • [9] PERSISTENT SENSITIZATION OF CLONIDINE-INDUCED HYPOKINESIA FOLLOWING ONE EXPOSURE TO A STRESSOR - POSSIBLE RELEVANCE TO PANIC DISORDER AND ITS TREATMENT
    ANTELMAN, SM
    KNOPF, S
    KOCAN, D
    EDWARDS, DJ
    [J]. PSYCHOPHARMACOLOGY, 1989, 98 (01) : 97 - 101
  • [10] ANTICONVULSANT AND OTHER EFFECTS OF DIAZEPAM GROW WITH TIME AFTER A SINGLE TREATMENT
    ANTELMAN, SM
    KOCAN, D
    EDWARDS, DJ
    KNOPF, S
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 33 (01) : 31 - 39