Modern genetics, ancient defenses, and potential therapies

被引:22
作者
Gregersen, Peter K. [1 ]
机构
[1] N Shore Long Isl Jewish Hlth Syst, Feinstein Inst Med Res, Robert S Boas Ctr Genom & Human Genet, Manhasset, NY 11030 USA
关键词
SYSTEMIC-LUPUS-ERYTHEMATOSUS; TOLL-LIKE RECEPTORS; AUTOIMMUNE-DISEASES; INCREASED RISK; VITILIGO; RECOGNITION; ASSOCIATION; INTERFERON; SLEV1; IL23R;
D O I
10.1056/NEJMe078017
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
引用
收藏
页码:1263 / 1266
页数:4
相关论文
共 16 条
[1]
Pathogen recognition and innate immunity [J].
Akira, S ;
Uematsu, S ;
Takeuchi, O .
CELL, 2006, 124 (04) :783-801
[2]
The emerging role of interferon in human systemic lupus erythematosus [J].
Baechler, EC ;
Gregersen, PK ;
Behrens, TI .
CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (06) :801-807
[3]
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes [J].
Cargill, Michele ;
Schrodi, Steven J. ;
Chang, Monica ;
Garcia, Veronica E. ;
Brandon, Rhonda ;
Callis, Kristina P. ;
Matsunami, Nori ;
Ardlie, Kristin G. ;
Civello, Daniel ;
Catanese, Joseph J. ;
Leong, Diane U. ;
Panko, Jackie M. ;
McAllister, Linda B. ;
Hansen, Christopher B. ;
Papenfuss, Jason ;
Prescott, Stephen M. ;
White, Thomas J. ;
Leppert, Mark F. ;
Krueger, Gerald G. ;
Begovich, Ann B. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (02) :273-290
[4]
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene [J].
Duerr, Richard H. ;
Taylor, Kent D. ;
Brant, Steven R. ;
Rioux, John D. ;
Silverberg, Mark S. ;
Daly, Mark J. ;
Steinhart, A. Hillary ;
Abraham, Clara ;
Regueiro, Miguel ;
Griffiths, Anne ;
Dassopoulos, Themistocles ;
Bitton, Alain ;
Yang, Huiying ;
Targan, Stephan ;
Datta, Lisa Wu ;
Kistner, Emily O. ;
Schumm, L. Philip ;
Lee, Annette T. ;
Gregersen, Peter K. ;
Barmada, M. Michael ;
Rotter, Jerome I. ;
Nicolae, Dan L. ;
Cho, Judy H. .
SCIENCE, 2006, 314 (5804) :1461-1463
[5]
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus [J].
Graham, RR ;
Kozyrev, SV ;
Baechler, EC ;
Reddy, MPL ;
Plenge, RM ;
Bauer, JW ;
Ortmann, WA ;
Koeuth, T ;
Escribano, MF ;
Pons-Estel, B ;
Petri, M ;
Daly, M ;
Gregersen, PK ;
Martin, J ;
Altshuler, D ;
Behrens, TW ;
Alarcón-Riquelme, ME .
NATURE GENETICS, 2006, 38 (05) :550-555
[6]
Genetics of autoimmune diseases - disorders of immune homeostasis [J].
Gregersen, Peter K. ;
Behrens, Timothy W. .
NATURE REVIEWS GENETICS, 2006, 7 (12) :917-928
[7]
NALP1 in vitiligo-associated multiple autoimmune disease [J].
Jin, Ying ;
Mailloux, Christina M. ;
Gowan, Katherine ;
Riccardi, Sheri L. ;
LaBerge, Greggory ;
Bennett, Dorothy C. ;
Fain, Pamela R. ;
Spritz, Richard A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (12) :1216-1225
[8]
Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo [J].
Laberge, G ;
Mailloux, CM ;
Gowan, K ;
Holland, P ;
Bennett, DC ;
Fain, PR ;
Spritz, RA .
PIGMENT CELL RESEARCH, 2005, 18 (04) :300-305
[9]
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors [J].
Leadbetter, EA ;
Rifkin, IR ;
Hohlbaum, AM ;
Beaudette, BC ;
Shlomchik, MJ ;
Marshak-Rothstein, A .
NATURE, 2002, 416 (6881) :603-607
[10]
Inflammatory caspases and inflammasomes: master switches of inflammation [J].
Martinon, F. ;
Tschopp, J. .
CELL DEATH AND DIFFERENTIATION, 2007, 14 (01) :10-22