Nutritional hypophosphatemic rickets secondary to Neocate® use

被引：12

作者：

Ali, S. Akhtar ^{[1
]}

Mathalikunnel, A. ^{[2
]}

Bhardwaj, V ^{[3
]}

Braskett, M. ^{[4
]}

Pitukcheewanont, P. ^{[1
]}

机构：

[1] Childrens Hosp Los Angeles, Ctr Endocrinol Diabet & Metab, Div Pediat, 4650 Sunset Blvd,61, Los Angeles, CA 90027 USA

[2] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA

[3] CHLA, Div Gastroenterol Hepatol & Nutr, Los Angeles, CA 90027 USA

[4] CHLA, Div Clin Immunol & Allergy, Los Angeles, CA 90027 USA

来源：

OSTEOPOROSIS INTERNATIONAL | 2019年 / 30卷 / 09期

关键词：

FRACTURES;

D O I：

10.1007/s00198-019-04836-8

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Elemental formula is commonly used in children with feeding intolerance. We describe two, medically complex and feeding tube dependent, patients exclusively fed with Neocate (R) who subsequently developed hypophosphatemic rickets. Both patients had gross motor decline and pain with physical touch. They were found to have low serum phosphorus, normal calcium, and vitamin D studies, with elevated alkaline phosphatase suggestive of nutritional hypophosphatemia. Both courses were complicated by hypocalcemia following formula change and phosphorus supplementation, highlighting the need for careful management of phosphate repletion in affected individuals. Diligent serial electrolyte monitoring as well as attention to bone health is needed in conjunction with elemental nutrition. Formula change led to restoration of calcium and phosphorus homeostasis and radiographic improvement in these patients.

引用

页码：1887 / 1891

页数：5

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