MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2

被引：352

作者：

Wu, Qiong

Jin, Haifeng

Yang, Zhiping

Luo, Guanhong

Lu, Yuanyuan

Li, Kai

Ren, Gui

Su, Tao

Pan, Yan

Feng, Bin

Xue, Zengfu

Wang, Xin ^{[1
]}

Fan, Daiming

机构：

[1] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 392卷 / 03期

关键词：

Proliferation; MiR-150; EGR2; Gastric cancer; Antagomirs; EXPRESSION PROFILE; MICRORNA; GROWTH; INHIBITION; CELLS;

D O I：

10.1016/j.bbrc.2009.12.182

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150 Collectively, our study demonstrated that overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2, suggesting a potential strategy for the development of miRNA-based treatment of gastric cancer. (C) 2010 Elsevier Inc All rights reserved

引用

页码：340 / 345

页数：6

共 21 条

[1]

MicroRNAs Differentially Expressed in ACTH-Secreting Pituitary Tumors [J].