Forensic implications of genetic analyses from degraded DNA-A review

被引：235

作者：

Alaeddini, Reza ^{[3
]}

Walsh, Simon J. ^{[1
,2
]}

Abbas, Ali ^{[3
]}

机构：

[1] Australian Fed Police, Forens Ctr, Canberra, ACT, Australia

[2] Australian Fed Police, Ctr Data, Canberra, ACT, Australia

[3] Univ Sydney, Sch Chem & Biomol Engn, Sydney, NSW 2006, Australia

来源：

FORENSIC SCIENCE INTERNATIONAL-GENETICS | 2010年 / 4卷 / 03期

关键词：

DNA degradation; Forensics; Cell death; Deoxyribonuclease; PCR; WHOLE GENOME AMPLIFICATION; PROGRAMMED CELL-DEATH; MITOCHONDRIAL-DNA; COPY-NUMBER; HUMAN REMAINS; ANCIENT DNA; DEOXYRIBONUCLEIC-ACID; MOLECULAR-CLONING; MISCODING LESIONS; SKELETAL REMAINS;

D O I：

10.1016/j.fsigen.2009.09.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Forensic DNA identification techniques are principally based on determination of the size or sequence of desired PCR products. The fragmentation of DNA templates or the structural modifications that can occur during the decomposition process can impact the outcomes of the analytical procedures. This study reviews the pathways involved in cell death and DNA decomposition and the subsequent difficulties these present in DNA analysis of degraded samples. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：148 / 157

页数：10

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