TGF-β stimulates glial-like differentiation in murine dental follicle precursor cells (mDFPCs)

被引：11

作者：

Felthaus, Oliver ^{[1
,2
]}

Ernst, Wolfgang ^{[3
]}

Driemel, Oliver ^{[2
]}

Reichert, Torsten E. ^{[2
]}

Schmalz, Gottfried ^{[1
]}

Morsczeck, Christian ^{[1
,3
]}

机构：

[1] Univ Regensburg, Dept Operat Dent & Periodontol, D-93053 Regensburg, Germany

[2] Univ Regensburg, Dept Oral & Maxillofacial Surg, D-93053 Regensburg, Germany

[3] Univ Regensburg, Inst Human Genet, D-93053 Regensburg, Germany

来源：

NEUROSCIENCE LETTERS | 2010年 / 471卷 / 03期

关键词：

Dental follicle cells; Glial differentiation; Transforming growth factor beta; Retinal progenitor cells; Glial fibrillar acidic protein; GFAP GENE PROMOTER; IN-VITRO; STEM-CELLS; NEURONAL DIFFERENTIATION; NEURAL DIFFERENTIATION; CULTURED ASTROCYTES; TRANSGENIC MICE; SONIC HEDGEHOG; EXPRESSION; GLIOGENESIS;

D O I：

10.1016/j.neulet.2010.01.037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Dental stem cells such as dental follicle precursor cells (DFPCs) are capable of neural-like differentiation. However, compared to neuroectodermal progenitor cells such as murine retinal progenitor cells (mRPCs) they show only a limited capacity for glial cell differentiation. in this study we tested the influence of cell signaling on glial differentiation of mDFPCs. These cells were treated with inhibitors and activators of the Sonic hedgehog-, the Wnt/beta-Catenin-, and the TGF-beta-pathway. After incubation only an activation of the TGF-beta-pathway showed a remarkable glial-like cell differentiation. In contrast gene expression of neural cell markets was not regulated. In conclusion, TGF-beta improved glial-like, but not neural-like, differentiation of mDFPCs. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：179 / 184

页数：6

共 18 条

[1]

Hedgehog signaling in vertebrate eye development: a growing puzzle [J].