Investigation of angiogenesis and its mechanism using zinc oxide nanoparticle-loaded electrospun tissue engineering scaffolds

被引：164

作者：

Augustine, Robin ^{[1
]}

Dominic, Edwin Anto ^{[2
]}

Reju, Indu ^{[2
]}

Kaimal, Balarama ^{[2
]}

Kalarikkal, Nandakumar ^{[1
,3
]}

Thomas, Sabu ^{[1
,4
]}

机构：

[1] Mahatma Gandhi Univ, Int & Inter Univ Ctr Nanosci & Nanotechnol, Kottayam 686560, Kerala, India

[2] Pushpagiri Inst Med Sci & Res Ctr, Pushpagiri Res Ctr, Tiruvalla 689101, Kerala, India

[3] Mahatma Gandhi Univ, Sch Pure & Appl Phys, Kottayam 686560, Kerala, India

[4] Mahatma Gandhi Univ, Sch Chem Sci, Kottayam 686560, Kerala, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 93期

关键词：

ENDOTHELIAL GROWTH-FACTOR; OXIDATIVE STRESS; EXPRESSION; POLYCAPROLACTONE; TOXICITY; NANORODS; SYSTEM; CELLS;

D O I：

10.1039/c4ra07361d

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Angiogenesis through tissue engineering scaffolds is an important factor that determines the success of a tissue engineering endeavor. Zinc oxide (ZnO) nanoparticles are well known for their ability to generate reactive oxygen species (ROS) which have a potential role in biological systems. ROS can induce angiogenesis through growth factor mediated mechanisms. Here, we report the fabrication of electrospun polycaprolactone scaffolds incorporated with ZnO nanoparticles and their ability to induce angiogenesis. This study demonstrated that the induction of angiogenesis was by the expression of key proangiogenic factors, fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF), upregulated due to the presence of ZnO nanoparticles. This is the first report suggesting the use of a metal/metal oxide nanoparticle in tissue engineering scaffolds to enhance angiogenesis.

引用

页码：51528 / 51536

页数：9

共 53 条

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