Role of integrins in enterocyte migration

被引:20
作者
Basson, MD
机构
[1] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA
[2] Connecticut Vet Affairs Hlth Care Syst, New Haven, CT USA
关键词
colonocyte; enterocyte; epithelium; healing; integrin; intestine; matrix; mucosa; restitution;
D O I
10.1111/j.1440-1681.1998.t01-10-.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. Enterocyte motility depends critically on cell-matrix interactions, Although still incompletely understood, these appear critically dependent upon integrin-mediated cell adhesion, 2. In addition to providing a mechanism for cell adhesion and traction, the integrins are likely to serve as true receptors for the matrix across which cell motility occurs, initiating signals by both mechanical and chemical means that alter cell phenotype and proliferation as well as cell motility, 3. Sound rationale now exists to postulate that soluble growth factors within the extracellular milieu regulate intestinal mucosal healing not only directly but also indirectly by modulating integrin expression and organization.
引用
收藏
页码:280 / 285
页数:6
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