Regulation of cyclin D-dependent kinase activity in rat liver regeneration

被引：25

作者：

Kato, A ^{[1
]}

Ota, S ^{[1
]}

Bamba, H ^{[1
]}

Wong, RM ^{[1
]}

Ohmura, E ^{[1
]}

Imai, Y ^{[1
]}

Matsuzaki, F ^{[1
]}

机构：

[1] Saitama Med Sch, Saitama Med Ctr, Dept Internal Med 1, Kawagoe, Saitama 3508550, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 245卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.8377

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of cyclin D-dependent kinase activity in tissue regeneration in vivo has not been fully described. In young adult rat liver after 70% partial hepatectomy, the association of cyclin D1 with cdk4 was significantly promoted during G1 phase and was maximal at 18 hr, corresponding mainly to late G1. Cyclin D1-dependent kinase activity also strongly increased during G1 phase. The timing of the induction of cyclin D1/cdk4 complex assembly correlated well with that of cyclin D1-dependent kinase activity. At 18 hr after partial hepatectomy, the amounts of CDK inhibitors p21(CIP1) and p27(KIP1) were also maximal, while only one-tenth of p21(CIP1) and of p27(KIP1) was associated with cyclin D1. These findings suggest that cyclin D1, cdk4 and their association act as promoting factors, and that both p21(CIP1) and p27(KIP1) may have physiological functions as adaptor proteins in additions to their roles as CDK inhibitors in rat liver regeneration. (C) 1998 Academic Press.

引用

页码：70 / 74

页数：5

共 21 条

[1] DISTINCT PATTERNS OF CYCLIN D1 REGULATION IN MODELS OF LIVER-REGENERATION AND HUMAN LIVER
ALBRECHT, JH
HU, MY
CERRA, FB
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 209 (02) : 648 - 655
[2] RIBONUCLEIC-ACID ISOLATED BY CESIUM-CHLORIDE CENTRIFUGATION
GLISIN, V
CRKVENJAKOV, R
BYUS, C
[J]. BIOCHEMISTRY, 1974, 13 (12) : 2633 - 2637
[3] Higgins GM, 1931, ARCH PATHOL, V12, P186
[4] Inactivation of the cyclin D-dependent kinase in the rat fibroblast cell line, 3Y1, induced by contact inhibition
Kato, A
Takahashi, H
Takahashi, Y
Matsushime, H
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (12) : 8065 - 8070
[5] New functional activities for the p21 family of CDK inhibitors
LaBaer, J
Garrett, MD
Stevenson, LF
Slingerland, JM
Sandhu, C
Chou, HS
Fattaey, A
Harlow, E
[J]. GENES & DEVELOPMENT, 1997, 11 (07) : 847 - 862
[6] LOYER P, 1994, J BIOL CHEM, V269, P2491
[7] Growth factor dependence of progression through G(1) and S phases of adult rat hepatocytes in vitro - Evidence of a mitogen restriction point in mid-late G(1)
Loyer, P
Cariou, S
Glaise, D
Bilodeau, M
Baffet, G
GuguenGuillouzo, C
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (19) : 11484 - 11492
[8] IDENTIFICATION AND PROPERTIES OF AN ATYPICAL CATALYTIC SUBUNIT (P34(PSK-J3)/CDK4) FOR MAMMALIAN-D TYPE-G1 CYCLINS
MATSUSHIME, H
EWEN, ME
STROM, DK
KATO, JY
HANKS, SK
ROUSSEL, MF
SHERR, CJ
[J]. CELL, 1992, 71 (02) : 323 - 334
[9] D-TYPE CYCLIN-DEPENDENT KINASE-ACTIVITY IN MAMMALIAN-CELLS
MATSUSHIME, H
QUELLE, DE
SHURTLEFF, SA
SHIBUYA, M
SHERR, CJ
KATO, JY
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (03) : 2066 - 2076
[10] COLONY-STIMULATING FACTOR-I REGULATES NOVEL CYCLINS DURING THE G1 PHASE OF THE CELL-CYCLE
MATSUSHIME, H
ROUSSEL, MF
ASHMUN, RA
SHERR, CJ
[J]. CELL, 1991, 65 (04) : 701 - 713

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