New steroidal glycosides from the fruits of Tribulus terrestris

被引：59

作者：

Bedir, E

Khan, IA ^{[1
]}

机构：

[1] Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[3] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 12期

关键词：

D O I：

10.1021/np000353b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new steroidal saponins (1-3) were isolated from the fruits of Tribulus terrestris. Their structures were assigned by spectroscopic methods (IR, HRESIMS, 1D- and 2D-NMR) as 26-O-beta -D-glucopyranosyl-(25S)-5 beta -furost-20(22)-en-3 beta ,26-diol-3-O-alpha -L-rhamnopyranosyl-(1->2)-[alpha -L-rhamnopyranosyl-(1->4)]-beta -D-glucopyranoside (1), 26-O-beta -D-glucopyranosyl-(25S)-5 beta -furost-20(22)-en-3 beta ,26-diol-3-O-alpha -L-rhamnopyranosyl-(1->2)- [beta -D-glucopyranosyl-(1->4)]-beta -D-galactopyranoside (2), and 25(S)-5 beta -spirostan-3 beta-alpha -3-O-alpha -L-rhamnopyranosyl-(1->2 -[beta -D-glucopyranosyl-(1->4)]-beta -D-galactopyranoside (3). Compound 3 showed cytotoxicity against a human malignant melanoma cell line (SK-MEL).

引用

页码：1699 / 1701

页数：3

共 13 条

[1] C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].