Role of Btk in B cell development and signaling

被引：64

作者：

Desiderio, S ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,HOWARD HUGHES MED INST,BALTIMORE,MD 21205

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(97)80107-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.

引用

页码：534 / 540

页数：7

共 65 条

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