Preparation and physicochemical properties of a novel hydroxyapatite/chitosan-silk fibroin composite

被引：123

作者：

Wang, Li ^{[1
]}

Li, Chunzhong ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2007年 / 68卷 / 04期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

hydroxyapatite; chitosan; silk fibroin; composite; chemical interaction; compressive strength;

D O I：

10.1016/j.carbpol.2006.08.010

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel hydroxyapatite/chitosan-silk fibroin (HA/CTS-SF) composite was prepared for bone repair and replacement by a coprecipitation method. It was revealed that the inorganic phase in the composite was carbonate-substituted HA with low crystallinity. The HA crystallites were found to be needle-like in shape with a typical size of 20-50nm in length and around 10nm in width. The composite exhibited a higher compressive strength than the precipitated HA without any organic source involved, which was closely related to the perfect incorporation of chitosan and SF macromolecules into the composite. The chemical interactions occurring between the mineral phase and the organic matrix were thought to improve the interfacial bonding and thus resulted in the enhanced mechanical property of the composite. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：740 / 745

页数：6

共 33 条

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