L1.1 is involved in spinal cord regeneration in adult zebrafish

被引：134

作者：

Becker, CG ^{[1
]}

Lieberoth, BC ^{[1
]}

Morellini, F ^{[1
]}

Feldner, J ^{[1
]}

Becker, T ^{[1
]}

Schachner, M ^{[1
]}

机构：

[1] Univ Hamburg, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany

来源：

JOURNAL OF NEUROSCIENCE | 2004年 / 24卷 / 36期

关键词：

regeneration; cell recognition molecule; spinal cord; brainstem; teleost; Danio rerio;

D O I：

10.1523/JNEUROSCI.2420-04.2004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional relevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.

引用

页码：7837 / 7842

页数：6

共 22 条

[1]

Asher R A, 2001, Prog Brain Res, V132, P611

[2] The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats [J].

Bareyre, FM ;

Kerschensteiner, M ;

Raineteau, O ;

Mettenleiter, TC ;

Weinmann, O ;

Schwab, ME .

NATURE NEUROSCIENCE, 2004, 7 (03) :269-277

[3] Tenascin-R as a repellent guidance molecule for newly growing and regenerating optic axons in adult zebrafish [J].

Becker, CG ;

Schweitzer, J ;

Feldner, J ;

Schachner, M ;

Becker, T .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2004, 26 (03) :376-389

[4]

Becker CG, 2003, J NEUROSCI, V23, P6232

[5]

Becker T, 1997, J COMP NEUROL, V377, P577, DOI 10.1002/(SICI)1096-9861(19970127)377:4<577::AID-CNE8>3.0.CO

[6]

2-#

[7]

Becker T, 1998, J NEUROSCI, V18, P5789

[8] Regenerating descending axons preferentially reroute to the gray matter in the presence of a general macrophage/microglial reaction caudal to a spinal transection in adult zebrafish [J].

Becker, T ;

Becker, CG .

JOURNAL OF COMPARATIVE NEUROLOGY, 2001, 433 (01) :131-147

[9]

Bernhardt RR, 1996, J COMP NEUROL, V376, P253, DOI 10.1002/(SICI)1096-9861(19961209)376:2<253::AID-CNE7>3.0.CO

[10]

2-2

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