Microbiota and the gut-liver axis: Bacterial translocation, inflammation and infection in cirrhosis

被引：240

作者：

Giannelli, Valerio ^{[1
]}

Di Gregorio, Vincenza ^{[1
]}

Iebba, Valerio ^{[2
]}

Giusto, Michela ^{[1
]}

Schippa, Serena ^{[2
]}

Merli, Manuela ^{[1
]}

Thalheimer, Ulrich ^{[3
]}

机构：

[1] Univ Roma La Sapienza, Med Clin, Dept Gastroenterol, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy

[3] Royal Devon & Exeter Fdn Trust, Exeter Liver Unit, Exeter EX2 5DW, Devon, England

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 45期

关键词：

Dysbiosis; Cirrhosis; Bacterial translocation; Inflammation; Infection; Bacterial overgrowth; Rifaximine; Lactulose; Liver; Gut; Portal hypertension; MESENTERIC LYMPH-NODES; GASTROINTESTINAL-TRACT; INDIGENOUS BACTERIA; INTESTINAL DECONTAMINATION; HEPATIC-ENCEPHALOPATHY; AUTONOMIC NEUROPATHY; PORTAL-HYPERTENSION; TRANSIT-TIME; OVERGROWTH; RATS;

D O I：

10.3748/wjg.v20.i45.16795

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Liver disease is associated with qualitative and quantitative changes in the intestinal microbiota. In cirrhotic patients the alteration in gut microbiota is characterized by an overgrowth of potentially pathogenic bacteria (i.e., gram negative species) and a decrease in autochthonous familiae. Here we summarize the available literature on the risk of gut dysbiosis in liver cirrhosis and its clinical consequences. We therefore described the features of the complex interaction between gut microbiota and cirrhotic host, the so called "gut-liver axis", with a particular attention to the acquired risk of bacterial translocation, systemic inflammation and the relationship with systemic infections in the cirrhotic patient. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of gut dysbiosis and its complication in liver cirrhosis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：16795 / 16810

页数：16

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