A new protocol for selective deprotection of N-tert-butoxycarbonyl protective group (t-boc) with Sn(OTf)2

被引：30

作者：

Bose, DS ^{[1
]}

Kumar, KK ^{[1
]}

Reddy, AVN ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Fine Chem Lab, Div Organ Chem 3, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 03期

关键词：

N-tert-butoxycarbonyl group; deprotection; Tin(II)-trifluoromethane sulfonate; solvent-free;

D O I：

10.1081/SCC-120015775

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method for the selective removal of N-Boc group by employing tin(II) trifluoromethanesulfonate [Sn(OTf)(2)] in CH2Cl2 or solvent-free conditions was developed. The scope of this procedure is explored for the deprotection of a variety of amines, including amino acid derivatives.

引用

页码：445 / 450

页数：6

共 18 条

[1] CATECHOL BORON HALIDES - MILD AND SELECTIVE REAGENTS FOR CLEAVAGE OF COMMON PROTECTING GROUPS [J].