Identification and characterization of a novel mouse plexin, plexin-A4

被引：61

作者：

Suto, F

Murakami, Y

Nakamura, F

Goshima, Y

Fujisawa, H ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Grp Dev Neurobiol,Chikusa Ku, Nagoya, Aichi 4648602, Japan

[2] JST Japan Sci & Technol Corp, CREST, Kawaguchi, Saitama 3320012, Japan

[3] Yokohama City Univ, Sch Med, Dept Pharmacol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

MECHANISMS OF DEVELOPMENT | 2003年 / 120卷 / 03期

关键词：

plexin; semaphorin; neuropilin; molecular cloning; in situ hybridization; neural development; axon guidance; growth cone collapse;

D O I：

10.1016/S0925-4773(02)00421-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plexins belonging to the plexin-A subfamily form complexes with neuropilins and propagate signals of class 3 semaphorins into neurons, even though they do not directly bind the semaphorins. In this study, we identified a new member of the plexin-A subfamily in the mice, plexin-A4, and showed that it was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1, plexin-A2 and plexin-A3). COS-7 cells coexpressing plexin-A4 with neuropilin-1 were induced to contract by Sema3A, a member of the class 3 semaphorin. Ectopic expression of plexin-A4 in mitral cells that are originally insensitive to Sema3A resulted in the collapse of growth cones in the presence of Sema3A. These results suggest that plexin-A4 plays a role in the propagation of Sema3A activities. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：385 / 396

页数：12

共 43 条

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