γδ T cells in host defense and epithelial cell biology

Recent studies have demonstrated increased numbers of gamma delta T cells in a variety of human infectious as well as noninfectious diseases. In some cases gamma delta T cells could be shown to destroy infected or transformed cells. Advances in the identification of ligands recognized by gamma delta T cells and the development of animal model systems to study these cells in vivo should overcome some of the major obstacles currently preventing a better understanding of gamma delta T cell function in immune responses. As we gain this knowledge it may become possible to design therapeutic strategies exploiting unique properties of gamma delta T cells to promote more effective immunity. (C) 1998 Academic Press.