Prenatal exposure to low-level polychlorinated biphenyls in relation to mental and motor development at 8 months

被引:62
作者
Daniels, JL
Longnecker, MP
Klebanoff, MA
Gray, KA
Brock, JW
Zhou, HB
Chen, Z
Needham, LL
机构
[1] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA
[2] NICHHD, Div Epidemiol Stat & Prevent Res, Rockville, MD USA
[3] NIEHS, Chem Exposure & Mol Biol Branch, Res Triangle Pk, NC 27709 USA
[4] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA
[5] NIEHS, Biostat Branch, Res Triangle Pk, NC 27709 USA
关键词
infant; mental status schedule; motor skills; polychlorinated biphenyls; prenatal exposure delayed effects;
D O I
10.1093/aje/kwg010
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The relation between exposure to low levels of polychlorinated biphenyls (PCBs), a class of persistent organic pollutants, and.cognitive and motor development in young children has been examined in several studies, and results have varied. The authors evaluated the association between prenatal exposure to PCBs and children's neurodevelopment using data from the Collaborative Perinatal Project. Pregnant women were enrolled from 1959 to 1965 from 12 sites. across the United States. PCBs were measured in maternal serum taken during pregnancy. To measure children's mental and psychomotor development at 8 months of age, the authors administered the Bayley Scales of Infant Development (means, 87 (standard deviation, 15) and 88 (standard deviation, 18), respectively). Overall, they did not observe a relation between prenatal PCB exposure and children's mental or psychomotor scores (n = 1,207; multivariate adjusted beta = 01 point per mug/liter increase of PCB, p = 0.71, and beta = 0.5, p = 0.14, respectively). The PCB-psychomotor score relation varied by study center (p < 0.05): The association was direct in some centers, inverse in others. This could not be attributed to variation in the timing or measurement of the child's neurodevelopment or analysis of PCBs because these were standardized across centers. The reasons for variation in results within this study and across other studies remain unclear.
引用
收藏
页码:485 / 492
页数:8
相关论文
共 31 条
[1]  
Bayley N., 1969, BAYLEY SCALES INFANT
[2]  
BOWMAN RE, 1981, NEUROTOXICOLOGY, V2, P251
[3]   An improved analysis for chlorinated pesticides and polychlorinated biphenyls (PCBs) in human and bovine sera using solid-phase extraction [J].
Brock, JW ;
Burse, VW ;
Ashley, DL ;
Najam, AR ;
Green, VE ;
Korver, MP ;
Powell, MK ;
Hodge, CC ;
Needham, LL .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1996, 20 (07) :528-536
[4]   MATERNAL AND ENVIRONMENTAL-FACTORS AFFECTING DEVELOPMENTAL OUTCOME OF INFANTS OF ADOLESCENT MOTHERS [J].
COLL, CG ;
VOHR, BR ;
HOFFMAN, J ;
OH, W .
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 1986, 7 (04) :230-236
[5]  
Darvill T, 2000, NEUROTOXICOLOGY, V21, P1029
[6]   DEVELOPMENT AFTER EXPOSURE TO POLYCHLORINATED-BIPHENYLS AND DICHLORODIPHENYL DICHLOROETHENE TRANSPLACENTALLY AND THROUGH HUMAN-MILK [J].
GLADEN, BC ;
ROGAN, WJ ;
HARDY, P ;
THULLEN, J ;
TINGELSTAD, J ;
TULLY, M .
JOURNAL OF PEDIATRICS, 1988, 113 (06) :991-995
[7]   Meta-analysis of continuous outcome data from individual patients [J].
Higgins, JPT ;
Whitehead, A ;
Turner, RM ;
Omar, RZ ;
Thompson, SG .
STATISTICS IN MEDICINE, 2001, 20 (15) :2219-2241
[8]   A GENERALIZATION OF SAMPLING WITHOUT REPLACEMENT FROM A FINITE UNIVERSE [J].
HORVITZ, DG ;
THOMPSON, DJ .
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1952, 47 (260) :663-685
[9]   Sources and implications of interstudy and interindividual variability in the developmental neurotoxicity of PCBs [J].
Jacobson, JL ;
Jacobson, SW .
NEUROTOXICOLOGY AND TERATOLOGY, 1996, 18 (03) :257-264
[10]  
JACOBSON SW, 1986, THEORY RES BEHAV PED, V3, P96