Effects of a vasopressin antagonist in women with dysmenorrhea

被引：35

作者：

Valentin, L ^{[1
]}

Sladkevicius, P

Kindahl, H

Broeders, A

Marsal, K

Melin, P

机构：

[1] Univ Lund, Univ Hosp, Dept Obstet & Gynecol, SE-20502 Malmo, Sweden

[2] Ferring AB, Malmo, Sweden

[3] Ferring Res Inst AB, Malmo, Sweden

[4] Swedish Univ Agr Sci, Dept Obstet & Gynecol, Uppsala, Sweden

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2000年 / 50卷 / 03期

关键词：

dysmenorrhea; vasopressin; vasopressin antagonist; Doppler ultrasound; intrauterine pressure;

D O I：

10.1159/000010319

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We compared menstrual pain, uterine contractility and blood circulation, and plasma concentrations of vasopressin and prostaglandin F-2 alpha metabolite in women with versus without primary dysmenorrhea, and determined the effects of a vasopressin antagonist, 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-oxytocin (Atosiban), on these parameters, Our results do not support the contention that vasopressin is involved in the etiology of dysmenorrhea, plasma concentrations of vasopressin being similar in dysmenorrheic women and controls, and the vasopressin antagonist Atosiban having no effect on menstrual pain, intrauterine pressure or uterine artery pulsatility index in dysmenorrheic women. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：170 / 177

页数：8

共 32 条

[1] VASCULARIZATION OF HUMAN ENDOMETRIUM - UTERINE BLOOD-FLOW IN HEALTHY CONDITION AND IN PRIMARY DYSMENORRHEA [J].