Stem cells and the impact of ROS signaling

被引：522

作者：

Bigarella, Carolina L. ^{[1
]}

Liang, Raymond ^{[1
,2
]}

Ghaffari, Saghi ^{[1
,2
,3
,4
,5
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Dev & Regenerat Biol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dev & Stem Cell Biol Multidisciplinary Training A, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Dept Med, Div Hematol & Oncol, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Black Family Stem Cell Inst, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

来源：

DEVELOPMENT | 2014年 / 141卷 / 22期

基金：

美国国家卫生研究院;

关键词：

Hematopoietic stem cells; ROS; Embryonic stem cells; Metabolism; Mitochondria; REGULATES HEMATOPOIETIC STEM; FOXO TRANSCRIPTION FACTORS; FREE-RADICAL THEORY; REDOX REGULATION; SELF-RENEWAL; OXIDATIVE STRESS; PERMEABILITY TRANSITION; GLYCOLYTIC METABOLISM; ENERGY-METABOLISM; P38; MAPK;

D O I：

10.1242/dev.107086

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

An appropriate balance between self-renewal and differentiation is crucial for stem cell function during both early development and tissue homeostasis throughout life. Recent evidence from both pluripotent embryonic and adult stem cell studies suggests that this balance is partly regulated by reactive oxygen species (ROS), which, in synchrony with metabolism, mediate the cellular redox state. In this Primer, we summarize what ROS are and how they are generated in the cell, as well as their downstream molecular targets. We then review recent findings that provide molecular insights into how ROS signaling can influence stem cell homeostasis and lineage commitment, and discuss the implications of this for reprogramming and stem cell ageing. We conclude that ROS signaling is an emerging key regulator of multiple stem cell populations.

引用

页码：4206 / 4218

页数：13

共 176 条

[1]

Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity [J].

Abbas, Hussein A. ;

Maccio, Daniela R. ;

Coskun, Suleyman ;

Jackson, James G. ;

Hazen, Amy L. ;

Sills, Tiffany M. ;

You, M. James ;

Hirschi, Karen K. ;

Lozano, Guillermina .

CELL STEM CELL, 2010, 7 (05) :606-617

[2]

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses [J].

Anastasiou, Dimitrios ;

Poulogiannis, George ;

Asara, John M. ;

Boxer, Matthew B. ;

Jiang, Jian-kang ;

Shen, Min ;

Bellinger, Gary ;

Sasaki, Atsuo T. ;

Locasale, Jason W. ;

Auld, Douglas S. ;

Thomas, Craig J. ;

Vander Heiden, Matthew G. ;

Cantley, Lewis C. .

SCIENCE, 2011, 334 (6060) :1278-1283

[3]

Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis [J].

Angkeow, P ;

Deshpande, SS ;

Qi, B ;

Liu, YX ;

Park, YC ;

Jeon, BH ;

Ozaki, M ;

Irani, K .

CELL DEATH AND DIFFERENTIATION, 2002, 9 (07) :717-725

[4]

Human Induced Pluripotent Stem Cell Lines Show Stress Defense Mechanisms and Mitochondrial Regulation Similar to Those of Human Embryonic Stem Cells [J].

Armstrong, Lyle ;

Tilgner, Katarzyna ;

Saretzki, Gabriele ;

Atkinson, Stuart P. ;

Stojkovic, Miodrag ;

Moreno, Ruben ;

Przyborski, Stefan ;

Lako, Majlinda .

STEM CELLS, 2010, 28 (04) :661-673

[5]

The evolving concept of cancer and metastasis stem cells [J].

Baccelli, Irene ;

Trumpp, Andreas .

JOURNAL OF CELL BIOLOGY, 2012, 198 (03) :281-293

[6]

The free radical theory of aging matures [J].

Beckman, KB ;

Ames, BN .

PHYSIOLOGICAL REVIEWS, 1998, 78 (02) :547-581

[7]

REX-1 Expression and p38 MAPK Activation Status Can Determine Proliferation/Differentiation Fates in Human Mesenchymal Stem Cells [J].

Bhandari, Dilli Ram ;

Seo, Kwang-Won ;

Roh, Kyoung-Hwan ;

Jung, Ji-Won ;

Kang, Soo-Kyung ;

Kang, Kyung-Sun .

PLOS ONE, 2010, 5 (05)

[8]

Reactive oxygen species activate the HIF-1α promoter via a functional NFκB site [J].

Bonello, Steve ;

Zahringer, Christian ;

BelAiba, Rachida S. ;

Djordjevic, Talija ;

Hess, John ;

Michiels, Carine ;

Kietzmann, Thomas ;

Goerlach, Agnes .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (04) :755-761

[9]

SIRT3 Reverses Aging-Associated Degeneration [J].

Brown, Katharine ;

Xie, Stephanie ;

Qiu, Xiaolei ;

Mohrin, Mary ;

Shin, Jiyung ;

Liu, Yufei ;

Zhang, Dan ;

Scadden, David T. ;

Chen, Danica .

CELL REPORTS, 2013, 3 (02) :319-327

[10]

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation [J].

Brunelle, JK ;

Bell, EL ;

Quesada, NM ;

Vercauteren, K ;

Tiranti, V ;

Zeviani, M ;

Scarpulla, RC ;

Chandel, NS .

CELL METABOLISM, 2005, 1 (06) :409-414

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