COX-2-derived prostacyclin confers atheroprotection on female mice

被引：342

作者：

Egan, KM

Lawson, JA

Fries, S

Koller, B

Rader, DJ

Smyth, EM

FitzGerald, GA ^{[1
]}

机构：

[1] Univ Penn, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA

[2] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA

来源：

SCIENCE | 2004年 / 306卷 / 5703期

关键词：

D O I：

10.1126/science.1103333

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Female gender affords relative protection from cardiovascular disease until the menopause. We report that estrogen acts on estrogen receptor subtype alpha to up-regulate the production of atheroprotective prostacyclin, PGI(2), by activation of cyclooxygenase 2 (COX-2). This mechanism restrained both oxidant stress and platelet activation that contribute to atherogenesis in female mice. Deletion of the PGI(2) receptor removed the atheroprotective effect of estrogen in ovariectomized female mice. This suggests that chronic treatment of patients with selective inhibitors of COX-2 could undermine protection from cardiovascular disease in premenopausal females.

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页码：1954 / 1957

页数：4

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