Quantification studies in continuous-flow 13C nuclear magnetic resonance spectroscopy by use of immobilized paramagnetic relaxation agents

被引:19
作者
Fischer, HH
Seiler, M
Ertl, TS
Eberhardinger, U
Bertagnolli, H
Schmitt-Willich, H
Albert, K
机构
[1] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
[2] Inst Phys Chem, D-70550 Stuttgart, Germany
[3] Schering AG, D-13342 Berlin, Germany
关键词
D O I
10.1021/jp021631d
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Different types of immobilized free radicals as well as immobilized paramagnetic gadolinium(Ill) complexes were synthesized and used as relaxation agents to shorten the spin-lattice relaxation times T-1 of analytes in quantitative continuous-flow C-13 nuclear magnetic resonance spectroscopy (NMR). The immobilized paramagnetic relaxation agents were characterized with electron paramagnetic resonance spectroscopy (EPR) and extended X-ray absorption fine structure spectroscopy (EXAFS). With these types of paramagnetic relaxation agents, it was possible to obtain a 4-fold increase in signal-to-noise ratio per unit time, and an almost quantitative NMR spectra in continuous-flow C-13 NMR spectroscopy could be acquired with this method.
引用
收藏
页码:4879 / 4886
页数:8
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