Beta blockers as anti-arrhythmic agents

被引：13

作者：

Anh, D ^{[1
]}

Marine, JE ^{[1
]}

机构：

[1] Henry Ford Hosp, Henry Ford Heart & Vasc Inst, Sect Cardiac Electrophysiol, Detroit, MI 48202 USA

来源：

HEART FAILURE REVIEWS | 2004年 / 9卷 / 02期

关键词：

adrenergic beta-antagonists; death; sudden; cardiac; anti-arrhythmia agents; ventricular fibrillation; tachycardia; ventricular;

D O I：

10.1023/B:HREV.0000046369.90417.db

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although beta-adrenergic blocking agents are not always considered anti-arrhythmic drugs, the results of several recent trials have suggested an anti-arrhythmic mechanism for at least part of their mortality benefit in the treatment of chronic congestive heart failure. We review background experimental and clinical evidence for the antiarrhythmic actions of beta-blockers and then review the results of published beta-blocker heart failure trials. A majority of trials showed improvement in overall survival as well as reduction in sudden death and ventricular arrhythmias with beta-blocker treatment. Although different effects were seen with different specific agents, these trials overall support a clinically significant anti-arrhythmic effect of several beta-blockers.

引用

页码：139 / 147

页数：9

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