Aberrant processing of oxidative DNA damage in systemic lupus erythematosus

被引：53

作者：

Evans, MD

Cooke, MS

Akil, M

Samanta, A

Lunec, J

机构：

[1] Univ Leicester, CMHT, Div Chem Pathol, Leicester LE1 9HN, Leics, England

[2] Leicester Royal Infirm NHS Trust, Dept Rheumatol, Leicester LE1 5WW, Leics, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 273卷 / 03期

关键词：

systemic lupus erythematosus; 8-oxo-2 '-deoxyguanosine; vitamin C; oxidative stress;

D O I：

10.1006/bbrc.2000.3078

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Defective DNA damage processing has been reported in systemic lupus erythematosus (SLE). Vitamin C may modulate formation/removal of the oxidative DNA lesion 8-oxo-2'-deoxyguanosine (8-oxodG). Baseline levels of 8-oxodG: measured in SLE serum, urine and PBMC DNA did not differ significantly from healthy subjects. In contrast to healthy subjects, no significant decrease in PBMC 8-oxodG or increase in urinary 8-oxodG was noted in vitamin C supplemented SLE patients. A significant, although attenuated, increase in serum 8-oxodG was detected in SLE patients, compared to healthy subjects. These data support putative abnormalities in the repair/processing of 8-oxodG in SLE, (C) 2000 Academic Press.

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收藏

页码：894 / 898

页数：5

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