SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population

被引：30

作者：

Babb, C. ^{[1
]}

Keet, E. Hanekom ^{[1
]}

van Helden, P. D. ^{[1
]}

Hoal, E. G. ^{[1
]}

机构：

[1] Univ Stellenbosch, Fac Hlth Sci, MRC, Ctr Mol & Cellular Biol,DST NRF Ctr Excellence Bi, ZA-7505 Tygerberg, South Africa

来源：

HUMAN GENETICS | 2007年 / 121卷 / 3-4期

关键词：

D O I：

10.1007/s00439-007-0335-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the Ipr1 gene. Polymorphisms in the human homologue, SP110, have been investigated in various populations with only one study finding an association with TB susceptibility. We investigated eight SP110 polymorphisms in a South African population, including two novel polymorphisms. No significant association was found with any of the polymorphisms investigated, including two polymorphisms that were previously found to be associated with TB susceptibility in West African populations. © Springer-Verlag 2007.

引用

页码：521 / 522

页数：2

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