Signaling from novel splice variants of hormone receptors in cancer

被引：5

作者：

Ding, WQ ^{[1
]}

Miller, LJ ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Ctr Basic Res Digest Dis, Rochester, MN 55905 USA

来源：

JOURNAL OF GASTROINTESTINAL CANCER | 2002年 / 31卷 / 1-3期

关键词：

splice variant; signaling; HER-2/neu; secretin receptor; CCK-B receptor; fibroblast growth factor receptor;

D O I：

10.1385/IJGC:31:1-3:31

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A number of splice variants of hormone receptors have recently been described in malignant neoplasms. Signaling by these novel receptor isoforms differ from their wild type counterparts, raising interesting questions as to possible roles in the initiation, progression, and metastatic potential of various tumors. This review summarizes recent findings on the signaling of novel variants of hormone receptors, including human HER-2/neu, the secretin receptor, the CCK-B/gastrin receptor and fibroblast growth factor receptor-2.

引用

页码：31 / 39

页数：9

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