Neuronal plasticity in persistent perennial allergic rhinitis

被引：50

作者：

Fischer, A

Wussow, A

Cryer, A

Schmeck, B

Noga, O

Zweng, M

Peiser, C

Dinh, QT

Heppt, W

Groneberg, DA

机构：

[1] Free Univ Berlin, Div Allergy Res, Occupat & Environm Med Res Unit, Otto Heubner Ctr,Sch Med, D-13353 Berlin, Germany

[2] Humboldt Univ, Div Allergy Res, Occupat & Environm Med Res Unit, Otto Heubner Ctr,Sch Med, D-13353 Berlin, Germany

[3] Med Univ Lubeck, Dept Occupat Med, D-23538 Lubeck, Germany

[4] Univ Freiburg, Karlsruhe Teaching Hosp, Dept Otorhinolaryngol, Karlsruhe, Germany

[5] Free Univ Berlin, Sch Med, Dept Med, D-1000 Berlin, Germany

[6] Humboldt Univ, Sch Med, Dept Med, D-1000 Berlin, Germany

[7] Hannover Med Sch, Dept Otorhinolaryngol, D-3000 Hannover, Germany

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2005年 / 47卷 / 01期

关键词：

D O I：

10.1097/01.jom.0000150238.77663.49

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 [公共卫生与预防医学]; 120402 [社会医学与卫生事业管理];

摘要：

Objective: Persistent perennial allergic rhinitis belongs to the most frequent diseases in occupational and environmental medicine. Because the innervation may play a role in the pathogenesis of the disease, the present study analyzed nasal mucosal nerve profiles. Methods: Neuropeptide-containing nerve fibers were examined using immunohistochemistry and related to eosinophil and mast cell numbers. Results: In contrast to constant numbers of mast cells, there was a significant increase in the number of eosinophils. Immunohistochemistry for calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP), and neuropeptide tyrosine (NPY) revealed abundant staining of mucosal nerves. Semiquantitative assessment Of nerve fiber neuropeptide density demonstrated a significant increase of VIP-positive fibers in rhinitis tissues. Conclusions: The present data indicate a differential regulation of neuropeptide-containing nerve fibers with increased numbers of VIPergic fibers suggesting a modulatory role of the upper airway innervation in perennial allergic rhinitis.

引用

页码：20 / 25

页数：6

共 51 条

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Prevalence and risk factors of occupational asthma among hairdressers in Turkey [J].