Hepatitis C virus genotypes in blood donors from the Federal District, Central Brazil

被引：8

作者：

Amorim, RMS

Oliveira, CP

Wyant, PS

Cerqueira, DM

Câmara, GNL

Flores, LS

Martins, RMB

Martins, CRF ^{[1
]}

机构：

[1] Univ Brasilia, Inst Biol, Dept Biol Celular, ICC Sul, BR-70919900 Brasilia, DF, Brazil

[2] Agcy Nacl Vigilancia Sanitaria, Brasilia, DF, Brazil

[3] Hemoctr Brasilia, Brasilia, DF, Brazil

[4] Univ Fed Goias, Goiania, Go, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2004年 / 99卷 / 08期

关键词：

hepatitis C virus; genotypes; Federal District; Central Brazil;

D O I：

10.1590/S0074-02762004000800019

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学]; 100103 [病原生物学];

摘要：

The objective of this study was to characterize hepatitis C virus (HCV) genotypes in blood donors from the Federal District, Central Brazil, and to compare HCV screening by serological assays and reverse transcriptase polymerase chain reaction (RT-PCR). Plasma samples from 57 individuals with reactive or indeterminate results in serological anti-HCV screening assays (ELISA or EIA) were tested for HCV RNA by RT-PCR. Die results from a of the HCV genome was amplified confirmatory LIA serological assay were also evaluated The 5' non-coding region of from 41 PCR positive samples (71.9 %), which were further characterized by nucleotide sequencing analysis. Of these, 60.9 % were of HCV genotype 1 and 39.1 % of genotype 3.

引用

页码：895 / 897

页数：3

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