Microenvironmental regulation of T cell development in the thymus

被引：70

作者：

Anderson, G ^{[1
]}

Harman, BC ^{[1
]}

Hare, KJ ^{[1
]}

Jenkinson, EJ ^{[1
]}

机构：

[1] Univ Birmingham, MRC, Dept Anat, Div Immun & Infect,Ctr Immune Regulat,Sch Med, Birmingham B15 2TT, W Midlands, England

来源：

SEMINARS IN IMMUNOLOGY | 2000年 / 12卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

microenvironment; stromal cell; thymocyte; thymus;

D O I：

10.1006/smim.2000.0260

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

T cell development in the thymus occurs through a series of events beginning with thymic colonization by migrant precursors and ending with the emigration of functionally competent CD4(+) and CD8(+) T cells to the periphery. It is well accepted that signals through the pre-T cell receptor (pre-TCR) and alpha-beta TCR (alpha beta TCR) complex play pivotal roles in the maturation of CD4(-) 8(-) and CD4(+) 8(+) thymocytes, respectively. It is clear that stromal cells constituting the thymic microenvironment provide non-TCR-mediated interactions which are essential for several developmental events. Examples of such will be discussed here in relation to early and late events in T cell development.

引用

页码：457 / 464

页数：8

共 62 条

[1]

Allelic exclusion of the T cell receptor β locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein [J].