Single-scattering spectroscopy for the endoscopic analysis of particle size in superficial layers of turbid media

被引:63
作者
Amelink, A
Bard, MPL
Burgers, SA
Sterenborg, HJCM
机构
[1] Erasmus MC, NL-3008 AE Rotterdam, Netherlands
[2] Erasmus MC, Dept Radiat Oncol, NL-3008 AE Rotterdam, Netherlands
[3] Erasmus MC, Dept Pulmonol, NL-3008 AE Rotterdam, Netherlands
关键词
D O I
10.1364/AO.42.004095
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We report on the development of an optical-fiber-based diagnostic tool that is sensitive to single-scattering events close to the fiber-optic probe tip. By using a single fiber to deliver and detect white light we optimized the detection probability of singly scattered photons from small depths. The sampling depth of this delivery-and-collection fiber was investigated by use of a tissue phantom. We found that for our phantom 90% of the single-scattering signal in the delivery-and-collection fiber originated from less than 200 mum from the fiber tip. The contribution of multiply scattered light from a greater depth to the signal was measured with an additional collection fiber. Several tissue phantoms demonstrated our fiber-optic probe's sensitivity to light scattering from superficial layers of tissue and thereby its potential to detect superficial precancerous epithelial lesions. 0(C)2003 Optical Society of America.
引用
收藏
页码:4095 / 4101
页数:7
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