A convenient and scaleable procedure for removing the Fmoc group in solution

被引：68

作者：

Sheppeck, JE ^{[1
]}

Kar, H ^{[1
]}

Hong, H ^{[1
]}

机构：

[1] ChemRx Adv Technol, S San Francisco, CA 94080 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 28期

关键词：

protecting groups; thiols; polymer support; supported reagents/reaction;

D O I：

10.1016/S0040-4039(00)00853-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved and simple reagent system was developed to facilitate solution-phase deprotection of Fmoc-protected amines. Catalytic DBU in the presence of an aliphatic or polymer-supported thiol rapidly removed the Fmoc group to provide the amine free base in excellent yields and purity on multi-gram scale. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：5329 / 5333

页数：5

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