Follicular development in transplanted fetal and neonatal mouse ovaries is influenced by the gonadal status of the adult recipient

被引:32
作者
Cox, SL
Shaw, J
Jenkin, G
机构
[1] Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia
[2] Monash Univ, Monash Inst Reprod & Dev, Clayton, Vic 3168, Australia
基金
英国医学研究理事会;
关键词
ovary; transplantation; follicular development;
D O I
10.1016/S0015-0282(00)00635-X
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective(s): To investigate the pattern of follicular development in transplanted fetal and neonatal mouse ovaries in the presence or absence of the recipient's own ovaries. Design: Controlled experiment. Setting: Academic research laboratory, Department of Physiology, Monash University, Clayton, Australia. Intervention(s): Mouse ovaries from 16-day-old fetuses, 3-day-old neonates, and 10-day-old neonates were transplanted under the kidney capsule of adult female mice, which either retained their own ovaries in situ or were bilaterally ovariectomized. Main Outcome Measure(s): Histologic analysis. Result(s): By 4 weeks after transplantation, fetal and neonatal ovaries transplanted to ovariectomized recipients displayed a pattern of follicular development similar to that observed in in situ adult mouse ovaries. In contrast, follicular development did not progress beyond the early antral stage in fetal and 3-day-old ovaries transplanted to recipients that retained their in situ ovaries. However, 10-day-old ovaries transplanted to recipients that retained their in situ ovaries displayed full follicular development and corpora lutea formation by 8 weeks after transplantation. Conclusion(s): Follicular development in transplanted immature ovarian tissue is influenced by the age of the donor ovary and gonadal status of the recipient. (C)2000 by American Society for Reproductive Medicine.
引用
收藏
页码:366 / 371
页数:6
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