Direct conversion of hydroxy aromatic compounds to heteroarylamines via a one-pot Smiles rearrangement procedure

被引：7

作者：

Weidner, JJ ^{[1
]}

Peet, NP ^{[1
]}

机构：

[1] Hoechst Mar Roussel Inc, Cincinnati, OH 45215 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 06期

关键词：

D O I：

10.1002/jhet.5570340636

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

8-Hydroxyquinoline (9) was converted to 8-aminequinoline (10) in a one-pot procedure involving alkylation with 2-bromo-2-methylpropionamide (2) followed by Smiles rearrangement and hydrolysis, in 41% yield. The scope and limitations of this new procedure were explored with additional hydroxyquinolines.

引用

页码：1857 / 1860

页数：4

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