The validity of the test of individual equivalence ratios

被引：7

作者：

Hwang, JTG ^{[1
]}

Wang, WZ

机构：

[1] Cornell Univ, Dept Math, Ithaca, NY 14583 USA

[2] Wright State Univ, Dept Math & Stat, Dayton, OH 45435 USA

来源：

BIOMETRIKA | 1997年 / 84卷 / 04期

关键词：

crossover design; symmetric distribution; unimodal distribution;

D O I：

10.1093/biomet/84.4.893

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We evaluate the validity of the test of individual equivalence ratios (TIER), a term coined by Anderson & Hauck (1990). The test was also proposed in Wellek (1989), It is proved to be a valid test under a class of unimodal symmetric distributions; this includes normal distributions. Since most bioequivalence studies involve data which are normal, or at least unimodal and symmetric, the test is typically valid. It is, however, not always valid, as shown by counter examples.

引用

页码：893 / 900

页数：8

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