Lentiviral nuclear import: a complex interplay between virus and host

被引：32

作者：

De Rijck, Jan

Vandekerckhove, Linos

Christ, Frauke

Debyser, Zeger

机构：

[1] Katholieke Univ Leuven, Lab Mol Virol & Gene Therapy, B-3000 Louvain, Belgium

[2] IRC KULAK, B-3000 Louvain, Belgium

来源：

BIOESSAYS | 2007年 / 29卷 / 05期

关键词：

D O I：

10.1002/bies.20561

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the capacity to infect non-dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal-facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host.

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收藏

页码：441 / 451

页数：11

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