A fibrinogen-binding protein of Staphylococcus lugdunensis

被引：36

作者：

Nilsson, M ^{[1
]}

Bjerketorp, J ^{[1
]}

Guss, B ^{[1
]}

Frykberg, L ^{[1
]}

机构：

[1] Swedish Univ Agr Sci, Dept Microbiol, SE-75007 Uppsala, Sweden

来源：

FEMS MICROBIOLOGY LETTERS | 2004年 / 241卷 / 01期

关键词：

Staphylococcus lugdunensis; fibrinogen-binding; Sdr-family; LPXTG; clumping factor; phage display;

D O I：

10.1016/j.femsle.2004.10.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A gene called fbl, encoding a Staphylococcus lugdunensis fibrinogen-binding protein, was identified by phage display. The encoded protein, Fbl, is a member of the Sdr-family, a group of staphylococcal cell surface proteins containing a characteristic serine-aspartate repeat region. The fibrinogen-binding domain was mapped to 313 amino acids, and shows, 62% identity to the corresponding region in clumping factor (ClfA) from Staphylococcus aureus. Anti-serum against ClfA cross-reacted with Fbl, and blocked S. lugdunensis adherence to fibrinogen. Twelve clinical isolates of S. lugdunensis analysed by Southern blot all had an fbl-like gene. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：87 / 93

页数：7

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