Ginsenoside Re enhances survival of human CD4+ T cells through regulation of autophagy

被引：39

作者：

Son, Young Min ^{[1
]}

Kwak, Chae Won ^{[1
]}

Lee, Yeo Jin ^{[1
]}

Yang, Deok-Chun ^{[2
,3
]}

Park, Byung-Chul ^{[4
]}

Lee, Woon Kyu ^{[5
]}

Han, Seung Hyun ^{[6
,7
]}

Yun, Cheol-Heui ^{[1
]}

机构：

[1] Seoul Natl Univ, Lab Prot Engn & Comparat Immunol, Dept Agr Biotechnol, Seoul 151921, South Korea

[2] Kyung Hee Univ, Korean Ginseng Ctr, Yongin 449701, Kyunggi Do, South Korea

[3] Kyung Hee Univ, Ginseng Genet Resource Bank, Yongin 449701, Kyunggi Do, South Korea

[4] Feed Anim Res Inst CJ Corp, Inchon 400103, South Korea

[5] Inha Univ, Ctr Adv Med Educ, Project BK21, Coll Med, Inchon 402751, South Korea

[6] Seoul Natl Univ, Dept Oral Microbiol & Immunol, Program BK21, Sch Dent, Seoul 110749, South Korea

[7] Seoul Natl Univ, Dent Res Inst, Sch Dent, Seoul 110749, South Korea

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2010年 / 10卷 / 05期

关键词：

Ginsenoside Re; CD4(+) T cells; Autophagy; Interferon related GTPase family M; Interferon-gamma; IMMUNITY; PROLIFERATION; ACTIVATION; PATHWAY; RH2;

D O I：

10.1016/j.intimp.2010.03.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

In the present study, we examined the effects of ginsenoside Re (Re) on cytokine expression, cytokine-dependent autophagy and cell survival in human CD4(+) T cells. When CD4(+) T cells isolated from human peripheral blood were treated with Re, LC3 and monodansylcadaverine (MDC), representative markers of autophagy, were decreased in a dose-dependent manner. Interestingly, Re suppressed the production of interferon-gamma (IFN-gamma) and immunity-related GTPase family M (IRGM) in CD4(+) T cells whereas no changes in other autophagy-related signaling molecules (ERK, p38 and AKT-mTOR-p70S6k) were found. Concomitantly, we observed that Re increased the proliferation of CD4(+) T cells with decreased cell death. Our results demonstrate that ginsenoside Re enhanced viability of CD4(+) T cells through the regulation of IFN-gamma-dependent autophagy activity. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：626 / 631

页数：6

共 24 条

[1]

The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals [J].

Ahn, JY ;

Choi, IS ;

Shim, JY ;

Yun, EK ;

Yun, YS ;

Jeong, GJ ;

Song, JY .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2006, 36 (01) :37-45

[2]

Conversion of major ginsenoside Rb1 to 20(S)-ginsenoside Rg3 by Microbacterium sp GS514 [J].

Cheng, Le-Qin ;

Na, Ju Ryun ;

Bang, Myun Ho ;

Kim, Myung Kyum ;

Yang, Deok-Chun .

PHYTOCHEMISTRY, 2008, 69 (01) :218-224

[3]

Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation [J].

Cho, JY ;

Kim, AR ;

Yoo, ES ;

Baik, KU ;

Park, MH .

PLANTA MEDICA, 2002, 68 (06) :497-500

[4]

Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A!Meyer [J].

Choi, Kwang-tae .

ACTA PHARMACOLOGICA SINICA, 2008, 29 (09) :1109-1118

[5]

Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity [J].

Corcelle, Elisabeth ;

Nebout, Marielle ;

Bekri, Soumeya ;

Gauthier, Nils ;

Hofman, Paul ;

Poujeol, Philippe ;

Fenichel, Patrick ;

Mograbi, Baharia .

CANCER RESEARCH, 2006, 66 (13) :6861-6870

[6]

Effect of Chito-oligosaccharide Supplementation on Immunity in Broiler Chickens [J].

Deng, Xingzhao ;

Li, Xiaojing ;

Liu, Pai ;

Yuan, Shulin ;

Zang, Jianjun ;

Li, Songyu ;

Piao, Xiangshu .

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 2008, 21 (11) :1651-1658

[7]

Feng, Carl G. ;

Zheng, Lixin ;

Jankovic, Dragana ;

Bafica, Andre ;

Cannons, Jennifer L. ;

Watford, Wendy T. ;

Chaussabel, Damien ;

Hieny, Sara ;

Caspar, Patricia ;

Schwartzberg, Pamela L. ;

Lenardo, Michael J. ;

Sher, Alan .

NATURE IMMUNOLOGY, 2008, 9 (11) :1279-1287

[8]

Interferon-inducible immunity-related GTPase Irgm1 regulates IFNγ-dependent host defense, lymphocyte survival and autophagy [J].

Feng, Carl G. ;

Zheng, Lixin ;

Lenardo, Michael J. ;

Sher, Alan .

AUTOPHAGY, 2009, 5 (02) :232-234

[9]

GANG YZ, 2006, CHEM BIODIVERS, V3, P187

[10]

Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages [J].

Harris, James ;

Master, Sharon S. ;

De Haro, Sergio A. ;

Delgado, Monica ;

Roberts, Esteban A. ;

Hope, Jayne C. ;

Keane, Joseph ;

Deretic, Vojo .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2009, 128 (1-3) :37-43

← 1 2 3 →