Factor V Leiden and prothrombin G20210A - Demystifying two common genetic predispositions to venous thrombosis

被引:15
作者
Deitcher, SR [1 ]
Caiola, E [1 ]
Jaffer, A [1 ]
机构
[1] Cleveland Clin Fdn, Dept Vasc Med, Sect Clin Thrombosis, Cleveland, OH 44195 USA
关键词
D O I
10.3949/ccjm.67.11.825
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Two recently discovered genetic abnormalities substantially increase the risk of venous thromboembolism. Yet we do not advocate screening for these abnormalities except in cases in which the information gained would affect the course of action.
引用
收藏
页码:825 / +
页数:7
相关论文
共 31 条
[1]   Activated protein C resistance and thrombosis:: Molecular mechanisms of hypercoagulable state due to FVR506Q mutation [J].
Dahlbäck, B .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1999, 25 (03) :273-289
[2]   FAMILIAL THROMBOPHILIA DUE TO A PREVIOUSLY UNRECOGNIZED MECHANISM CHARACTERIZED BY POOR ANTICOAGULANT RESPONSE TO ACTIVATED PROTEIN-C - PREDICTION OF A COFACTOR TO ACTIVATED PROTEIN-C [J].
DAHLBACK, B ;
CARLSSON, M ;
SVENSSON, PJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (03) :1004-1008
[3]   PHYSIOLOGICAL ANTICOAGULATION - RESISTANCE TO ACTIVATED PROTEIN-C AND VENOUS THROMBOEMBOLISM [J].
DAHLBACK, B .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (03) :923-927
[4]   Risk of venous thromboembolism in users of hormone replacement therapy [J].
Daly, E ;
Vessey, MP ;
Hawkins, MN ;
Carson, JL ;
Gough, P ;
Marsh, S .
LANCET, 1996, 348 (9033) :977-980
[5]   Epidemiology of factor V Leiden: Clinical implications [J].
De Stefano, V ;
Chiusolo, P ;
Paciaroni, K ;
Leone, G .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 1998, 24 (04) :367-379
[6]   The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation [J].
De Stefano, V ;
Martinelli, I ;
Mannucci, PM ;
Paciaroni, K ;
Chiusolo, P ;
Casorelli, I ;
Rossi, E ;
Leone, G .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (11) :801-806
[7]  
GRIFFIN JH, 1993, BLOOD, V82, P1989
[8]   RESISTANCE TO ACTIVATED PROTEIN-C AS A BASIS FOR VENOUS THROMBOEMBOLISM ASSOCIATED WITH PREGNANCY AND ORAL-CONTRACEPTIVES [J].
HELLGREN, M ;
SVENSSON, PJ ;
DAHLBACK, B .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1995, 173 (01) :210-213
[9]   Risk of hospital admission for idiopathic venous thromboembolism among users of postmenopausal oestrogens [J].
Jick, H ;
Derby, LE ;
Myers, MW ;
Vasilakis, C ;
Newton, KM .
LANCET, 1996, 348 (9033) :981-983
[10]   VENOUS THROMBOSIS DUE TO POOR ANTICOAGULANT RESPONSE TO ACTIVATED PROTEIN-C - LEIDEN THROMBOPHILIA STUDY [J].
KOSTER, T ;
ROSENDAAL, FR ;
DERONDE, H ;
BRIET, E ;
VANDENBROUCKE, JP ;
BERTINA, RM .
LANCET, 1993, 342 (8886-7) :1503-1506