A short synthesis of the trisaccharide building block of the N-linked glycans

被引：51

作者：

Dudkin, VY ^{[1
]}

Crich, D ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(03)00102-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient preparation of the core trisaccharide of N-linked glycoproteins containing P-azido functionality at the reducing terminus is described. In the synthesis, triflate-mediated direct beta-mannosylation was employed for the formation of the beta-D-Man-(1-->4)-GlcNAc linkage; the anomeric azide installation was achieved through oxazoline ring opening. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1787 / 1789

页数：3

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