Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits

被引：38

作者：

Bhouri, Wissem ^{[1
]}

Derbel, Safa ^{[1
]}

Skandrani, Ines ^{[1
]}

Boubaker, Jihed ^{[1
]}

Bouhlel, Ines ^{[1
]}

Sghaier, Mohamed B. ^{[1
]}

Kilani, Soumaya ^{[1
]}

Mariotte, Anne M. ^{[2
]}

Dijoux-Franca, Marie G. ^{[2
]}

Ghedira, Kamel ^{[1
]}

Chekir-Ghedira, Leila ^{[1
]}

机构：

[1] Fac Pharm Med Dent Monastir, Unite Pharmacognosie Biol Mol 99 UR 07 03, Monastir 5000, Tunisia

[2] UJF, Dept Pharmacochim Mol, UMR 5063, CNRS,UFR Pharm Grenoble, F-38706 La Tronche, France

来源：

TOXICOLOGY IN VITRO | 2010年 / 24卷 / 02期

关键词：

Antigenotoxic effect; Antioxidant capacity; Digallic acid; Genotoxic effect; SOS chromotest; LIPID-PEROXIDATION; EXTRACTS; FLAVONOIDS; ASSAY; MUTAGENICITY; RESVERATROL; MECHANISMS; PROOXIDANT; INHIBITORS; INDUCTION;

D O I：

10.1016/j.tiv.2009.06.024

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

The digallic acid obtained from the fruit Pistacia lentiscus exhibits an inhibitory activity against nitrofurantoine and B[a]P induced genotoxicity when tested by the SOS chromotest bacterial assay system in the presence of Escherichia coli PQ37 strain. The antioxidant activity of the tested compound was determined by its ability to scavenge the free radical ABTS(+center dot), to inhibit the xanthine oxidase, involved in the generation of free radicals, and to inhibit the lipid peroxidation induced by H2O2 in the K562 cell line. Our results revealed that digallic acid shows an important free radical scavenging activity towards the ABTS(+center dot) radical (99%) and protection against lipid peroxidation (68%). (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：509 / 515

页数：7

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