Synthesis and activity of 3-epi-actinobolin

被引：7

作者：

Adachi, H ^{[1
]}

Nishimura, Y ^{[1
]}

Kondo, S ^{[1
]}

Takeuchi, T ^{[1
]}

机构：

[1] Inst Microbial Chem, Shinagawa Ku, Tokyo 141, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 02期

关键词：

D O I：

10.7164/antibiotics.51.202

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

3-epi-Actinobolin was synthesized by the chemical transformation of actinobolin involving a key step of the reconstruction of fused delta-lacton skelton via intramolecular acylation reaction. The analogue with low toxicity weakly inhibits Gram-positive and Gram-negative bacteria.

引用

页码：202 / 209

页数：8

共 26 条

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