Interpretation of expression-profiling results obtained from different platforms and tissue sources: examples using prostate cancer data

被引:8
作者
Chiorino, G
Acquadro, F
Grand, MM
Viscomi, S
Segir, R
Gasparini, M
Dotto, P
机构
[1] Lab Canc Pharmacogenomics, Fondo Edo Tempia, I-13900 Biella, Italy
[2] Univ Milan, Inst Med Stat & Biometry, Milan, Italy
[3] Politecn Torino, Dept Math, I-10129 Turin, Italy
[4] Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Lausanne, Switzerland
关键词
expression signatures; processing techniques; platforms; data standardisation;
D O I
10.1016/j.ejca.2004.07.029
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The analysis of expression signatures is a powerful tool for the classification of cancer and other tissue samples. Several protocols and platforms are available on the market, and these lead to both confirmatory and complementary results. We review the main processing techniques for cross-platform comparisons and the different tissue sources for cancer profiling. Some examples and the cross-interpretation of bibliographic data related to prostate cancer are also presented. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2592 / 2603
页数:12
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