Synthesis of various 2H-benzopyran compounds and their kinetic resolution by asymmetric hydrolysis of their racemic acetates mediated by lipases

被引：28

作者：

Goujon, JY ^{[1
]}

Zammattio, F ^{[1
]}

Kirschleger, B ^{[1
]}

机构：

[1] Fac Sci & Tech, CNRS, UMR 6513, Organ Synth Lab, F-44072 Nantes 03, France

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(00)00176-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation of 2H-benzopyrans from bromophenols and tertiary allylic alcohols is described. The reaction is characterised by its mildness, good yields and ease of work-up. Kinetic resolution of the latter up to 95% ee was obtained by using enzyme-catalysed enantioselective hydrolysis. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2409 / 2420

页数：12

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