Free Radical Theory of Aging: Implications in Male Infertility

被引：70

作者：

Desai, Nisarg

Sabanegh, Edmund, Jr.

Kim, Taesoo

Agarwal, Ashok ^{[1
]}

机构：

[1] Cleveland Clin, Ctr Reprod Med, Glickman Urol & Kidney Inst, Cleveland, OH 44195 USA

来源：

UROLOGY | 2010年 / 75卷 / 01期

关键词：

BROWN-NORWAY RAT; OXIDATIVE STRESS; DNA-DAMAGE; MALE AGE; INDUCED APOPTOSIS; SEMEN QUALITY; MALE GERMLINE; LEYDIG-CELLS; PATERNAL AGE; TELOMERASE;

D O I：

10.1016/j.urology.2009.05.025

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

This review examines the effect of mitochondrial generation of reactive oxygen species (ROS) and aging on human spermatozoa and seminal antioxidants. We discuss the effect of continuous ROS production on biomarkers of aging, such as germ cell telomeres and telomerase, lipofuscin, and amyloid. These markers may be responsible for telomere shortening and subsequent decrease in sperm count, decline in testosterone concentration, and decline in motility with aging. Excessive ROS can also damage mitochondrial deoxyribonucleic acid and sperm nuclear DNA, contributing to paternally transmitted diseases. ROS generation has a central role in the pathophysiology of age-related decrease in male fertility. UROLOGY 75: 14-19, 2010. (C) 2010 Elsevier Inc.

引用

收藏

页码：14 / 19

页数：6

相关论文

共 50 条

[1] Clinical relevance of oxidative stress in male factor infertility: An update [J].

Agarwal, Ashok ;

Makker, Kartikeya ;

Sharma, Rakesh .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2008, 59 (01) :2-11

[2] Telomere instability in the male germline [J].

Baird, DM ;

Britt-Compton, B ;

Rowson, J ;

Amso, NN ;

Gregory, L ;

Kipling, D .

HUMAN MOLECULAR GENETICS, 2006, 15 (01) :45-51

[3] Fertility and ageing [J].

Baird, DT ;

Collins, J ;

Egozcue, J ;

Evers, LH ;

Gianaroli, L ;

Leridon, H ;

Sunde, A ;

Templeton, A ;

Van Steirteghem, A ;

Cohen, J ;

Crosignani, PG ;

Devroey, P ;

Diedrich, K ;

Fauser, BCJM ;

Fraser, J ;

Glasier, A ;

Liebaers, I ;

Mautone, G ;

Penney, G ;

Tarlatzis, B .

HUMAN REPRODUCTION UPDATE, 2005, 11 (03) :261-276

[4] The free radical theory of aging matures [J].

Beckman, KB ;

Ames, BN .

PHYSIOLOGICAL REVIEWS, 1998, 78 (02) :547-581

[5] AGE-RELATED ACCUMULATION OF CONGOPHILIC FIBRILLAR INCLUSIONS IN ENDOCRINE-CELLS [J].

BOHL, J ;

STEINMETZ, H ;

STORKEL, S .

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1991, 419 (01) :51-58

[6] Apoptosis in human unfertilized oocytes after intracytoplasmic sperm injection [J].

Bosco, L ;

Ruvolo, G ;

Morici, G ;

Manno, M ;

Cittadini, E ;

Roccheri, MC .

FERTILITY AND STERILITY, 2005, 84 (05) :1417-1423

[7] Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells [J].

Cao, LC ;

Leers-Sucheta, S ;

Azhar, S .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2004, 88 (01) :61-67

[8] Age-related increase of reactive oxygen species in neat semen in healthy fertile men [J].

Cocuzza, Marcello ;

Athayde, Kelly S. ;

Agarwal, Ashok ;

Sharma, Rakesh ;

Pagani, Rodrigo ;

Lucon, Antonio M. ;

Srougi, Miguel ;

Hallak, Jorge .

UROLOGY, 2008, 71 (03) :490-494

[9]

Cocuzza Marcello, 2007, Int. braz j urol., V33, P603, DOI 10.1590/S1677-55382007000500002

[10] Telomerase activity in the testis of infertile patients with selected causes [J].

Fujisawa, M ;

Tanaka, H ;

Tatsumi, N ;

Okada, H ;

Arakawa, S ;

Kamidono, S .

HUMAN REPRODUCTION, 1998, 13 (06) :1476-1479

← 1 2 3 4 5 →