Ursolic acid: A potent inhibitor of superoxides produced in the cellular system

被引：72

作者：

Ali, Muhammad S. ^{[1
]}

Ibrahim, Syed A. ^{[1
]}

Jalil, Saima ^{[1
]}

Choudhary, Muhammad I. ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

来源：

PHYTOTHERAPY RESEARCH | 2007年 / 21卷 / 06期

关键词：

Leonurus cardiaca; Lamiaceae; triterpenoids; ursane; antiinflammatory activity; superoxide scavenging activity;

D O I：

10.1002/ptr.2108

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Triterpenoids of ursane class: ursolic acid, ilelatifol D, corosolic acid and euscaphic acid were isolated for the first time from Leonurus cardiaca, a member of the family Lamiaceae. The isolated compounds were tested for their cell-based antiinflammatory potential by suppressing respiratory burst activity and superoxide scavenging property by using xanthine/xanthine oxidase system to produce superoxides in the cell-free system. Ursolic acid was found to be an excellent inhibitor for the superoxides produced in the cellular system, while the same was inactive in the superoxide scavenging activity in cell-free system. Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：558 / 561

页数：4

共 11 条

[1] Protective effects of melatonin in zymosan-activated plasma-induced paw inflammation [J].

Costantino, G ;

Cuzzocrea, S ;

Mazzon, E ;

Caputi, AP .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 363 (01) :57-63

[2] PREHISPANOLONE, A LABDANE DITERPENE FROM LEONURUS-HETEROPHYLLUS [J].

HON, PM ;

LEE, CM ;

SHANG, HS ;

CUI, YX ;

WONG, HNC ;

CHANG, HM .

PHYTOCHEMISTRY, 1991, 30 (01) :354-356

[3]

HON PM, 1993, PHYTOCHEMISTRY, V33, P639, DOI 10.1016/0031-9422(93)85464-3

[4]

KUANG HX, 1989, CHEM PHARM BULL, V37, P2232

[5]

Nishimura Keiichi, 2000, Natural Medicines, V54, P297

[6]

NUMATA A, 1989, CHEM PHARM BULL, V37, P648

[7] Neutrophil-associated inflammatory responses in rats are inhibited by phenylarsine oxide [J].

Roussin, A ;

LeCabec, V ;

Lonchampt, M ;

DeNadai, J ;

Canet, E ;

MaridonneauParini, I .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 322 (01) :91-96

[8] PHORBOL ESTER-INDUCED PRIMING OF SUPEROXIDE GENERATION BY PHOSPHATIDIC ACID-STIMULATED NEUTROPHILS AND GRANULE-FREE NEUTROPHIL CYTOPLASTS [J].

SIDDIQUI, RA ;

ENGLISH, D ;

HARVEY, K ;

CUI, Y ;

MARTIN, MI ;

WENTLAND, J ;

AKARD, L ;

JANSEN, J ;

THOMPSON, J ;

GARCIA, JGN .

JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 58 (02) :189-195

[9] Superoxide produced by activated neutrophils efficiently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: a simple colorimetric assay for measuring respiratory burst activation and for screening anti-inflammatory agents [J].

Tan, AS ;

Berridge, MV .

JOURNAL OF IMMUNOLOGICAL METHODS, 2000, 238 (1-2) :59-68

[10]

WEISS RF, 1985, HERBAL MED, P186

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