Raltegravir penetration in the cerebrospinal fluid of HIV-positive patients

被引:12
作者
Calcagno, Andrea [1 ]
Bonora, Stefano [1 ]
Bertucci, Roberto [1 ]
Lucchini, Anna [1 ]
D'Avolio, Antonio [1 ]
Di Perri, Giovanni [1 ]
机构
[1] Univ Turin, Dept Infect Dis, I-10149 Turin, Italy
关键词
CENTRAL-NERVOUS-SYSTEM; SIMULTANEOUS QUANTIFICATION; ANTIRETROVIRAL AGENTS; INTEGRASE INHIBITOR; INFECTED PATIENTS; PLASMA;
D O I
10.1097/QAD.0b013e3283319954
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:931 / 932
页数:2
相关论文
共 8 条
[1]   Raltegravir: The First HIV Integrase Inhibitor [J].
Cocohoba, Jennifer ;
Dong, Betty J. .
CLINICAL THERAPEUTICS, 2008, 30 (10) :1747-1765
[2]   An HPLC-PDA Method for the Simultaneous Quantification of the HIV Integrase Inhibitor Raltegravir, the New Nonnucleoside Reverse Transcriptase Inhibitor Etravirine, and 11 Other Antiretroviral Agents in the Plasma of HIV-Infected Patients [J].
D'Avolio, Antonio ;
Baietto, Lorena ;
Siccardi, Marco ;
Sciandra, Mauro ;
Simiele, Marco ;
Oddone, Valentina ;
Bonora, Stefano ;
Di Perri, Giovanni .
THERAPEUTIC DRUG MONITORING, 2008, 30 (06) :662-669
[3]   HPLC-MS method for the simultaneous quantification of the new HIV protease inhibitor darunavir, and 11 other antiretroviral agents in plasma of HIV-infected patients [J].
D'Avolio, Antonio ;
Siccardi, Marco ;
Sciandra, Mauro ;
Lorena, Baietto ;
Bonora, Stefano ;
Trentini, Laura ;
Di Perri, Giovanni .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 859 (02) :234-240
[4]   Antiretroviral drugs and the central nervous system [J].
Enting, RH ;
Hoetelmans, RMW ;
Lange, JMA ;
Burger, DM ;
Beijnen, JH ;
Portegies, P .
AIDS, 1998, 12 (15) :1941-1955
[5]   Metabolism and disposition in humans of raltegravir (MK-0518), an Anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme [J].
Kassahun, Kelem ;
McIntosh, Ian ;
Cui, Donghui ;
Hreniuk, David ;
Merschman, Shelia ;
Lasseter, Kenneth ;
Azrolan, Neal ;
Iwamoto, Marian ;
Wagner, John A. ;
Wenning, Larissa A. .
DRUG METABOLISM AND DISPOSITION, 2007, 35 (09) :1657-1663
[6]   Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system [J].
Letendre, Scott ;
Marquie-Beck, Jennifer ;
Capparelli, Edmund ;
Best, Brookie ;
Clifford, David ;
Collier, Ann C. ;
Gelman, Benjamin B. ;
McArthur, Justin C. ;
McCutchan, J. Allen ;
Morgello, Susan ;
Simpson, David ;
Grant, Igor ;
Ellis, Ronald J. .
ARCHIVES OF NEUROLOGY, 2008, 65 (01) :65-70
[7]   Modulation of P-glycoprotein at the blood-brain barrier: Opportunities to improve central nervous system pharmacotherapy [J].
Miller, David S. ;
Bauer, Bjoern ;
Hartz, Anika M. S. .
PHARMACOLOGICAL REVIEWS, 2008, 60 (02) :196-209
[8]   Effect of Rifampin, a Potent Inducer of Drug-Metabolizing Enzymes, on the Pharmacokinetics of Raltegravir [J].
Wenning, Larissa A. ;
Hanley, William D. ;
Brainard, Diana M. ;
Petry, Amelia S. ;
Ghosh, Kalyan ;
Jin, Bo ;
Mangin, Eric ;
Marbury, Thomas C. ;
Berg, Jolene K. ;
Chodakewitz, Jeffrey A. ;
Stone, Julie A. ;
Gottesdiener, Keith M. ;
Wagner, John A. ;
Iwamoto, Marian .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (07) :2852-2856