Sequence, structure, and chromosomal mapping of the mouse Lgals6 gene, encoding galectin-6

被引：34

作者：

Gitt, MA

Xia, YR

Atchison, RE

Lusis, AJ

Barondes, SH

Leffler, H

机构：

[1] Univ Calif San Francisco, Dept Psychiat, Ctr Neurobiol & Psychiat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Sch Med, Dept Microbiol & Mol Genet, Los Angeles, CA 90024 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1998年 / 273卷 / 05期

关键词：

D O I：

10.1074/jbc.273.5.2961

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the accompanying paper (Gitt, M, A., Colnot, C., Poirier, F., and Barondes, S. H., and Leffler, H. (1998) J. Biol. Chem. 273, 2954-2960), we reported that mouse gastrointestinal tract specifically expresses two closely related galectins, galectins-4 and -6, each with two carbohydrate recognition domains in the same peptide. Here, we report the isolation, characterization, and chromosomal mapping of the complete mouse Lgals6 gene, which encodes galectin-6, and of a fragment of a distinct gene, Lgals4, which encodes galectin-4, The coding sequence of galectin-6 is specified by eight exons. The upstream region contains two putative promoters. Both Lgals6 and the closely related Lgals4 are clustered together about 3.2 centimorgans proximal to the apoE gene on mouse chromosome 7. The syntenic human region is 19q13.1-13.3.

引用

页码：2961 / 2970

页数：10

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