HIV and bone mineral density

被引:58
作者
Mallon, Patrick W. G. [1 ,2 ]
机构
[1] Univ Coll Dublin, Sch Med & Med Sci, HIV Mol Res Grp, Dublin 2, Ireland
[2] Mater Misericordiae Univ Hosp, Dept Infect Dis, Dublin, Ireland
基金
爱尔兰科学基金会;
关键词
antiretroviral toxicity; bisphosphonates; bone mineral density; HIV; non-AIDS morbidity; VITAMIN-D DEFICIENCY; ANTIRETROVIRAL THERAPY; INFECTED MEN; CARDIOVASCULAR-DISEASE; RISK-FACTORS; IMMUNODEFICIENCY; OSTEOPOROSIS; OSTEOPENIA; WOMEN; ASSOCIATION;
D O I
10.1097/QCO.0b013e328334fe9a
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Purpose of review This review details the clinical aspects and pathogenesis of low bone mineral density (BMD) in HIV, discusses broad management issues and outlines areas in which our understanding of this condition is incomplete. Recent findings Low BMD is prevalent in HIV-infected patients, with traditional risk factors, HIV infection and exposure to antiretroviral therapy all contributing. The role of specific antiretrovirals in the development of low BMD remains controversial, but most changes arise at either antiretroviral therapy initiation or switch. Summary Further research is needed to clarify mechanisms underlying low BMD in HIV, whether low BMD will translate to increased fractures and to determine the correct therapeutic approach to low BMD in HIV, particularly in younger HIV-infected patients.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 50 条
[1]   Morphologic and metabolic abnormalities in vertically HIV-infected children and youth [J].
Aldrovandi, Grace M. ;
Lindsey, Jane C. ;
Jacobson, Denise L. ;
Zadzilka, Amanda ;
Sheeran, Elizabeth ;
Moye, Jack ;
Borum, Peggy ;
Meyer, William A., III ;
Hardin, Dana S. ;
Mulligan, Kathleen .
AIDS, 2009, 23 (06) :661-672
[2]  
[Anonymous], 2019, ANN EPIDEMIOLOGICAL
[3]   HIV infection and bone mineral density in middle-aged women [J].
Arnsten, JH ;
Freeman, R ;
Howard, AA ;
Floris-Moore, M ;
Santoro, N ;
Schoenbaum, EE .
CLINICAL INFECTIOUS DISEASES, 2006, 42 (07) :1014-1020
[4]   Decreased bone mineral density and increased fracture risk in aging men with or at risk for HIV infection [J].
Arnsten, Julia H. ;
Freeman, Ruth ;
Howard, Andrea A. ;
Floris-Moore, Michelle ;
Lo, Yungtai ;
Klein, Robert S. .
AIDS, 2007, 21 (05) :617-623
[5]   Low body weight mediates the relationship between HIV infection and low bone mineral density: A meta-analysis [J].
Bolland, Mark J. ;
Grey, Andrew B. ;
Gamble, Greg D. ;
Reid, Ian R. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (12) :4522-4528
[6]   Bone mineral density remains stable in HAART-treated HIV-infected men over 2 years [J].
Bolland, Mark J. ;
Grey, Andrew B. ;
Horne, Anne M. ;
Briggs, Simon E. ;
Thomas, Mark G. ;
Ellis-Pegler, Rod B. ;
Woodhouse, Andrew F. ;
Gamble, Greg D. ;
Reid, Ian R. .
CLINICAL ENDOCRINOLOGY, 2007, 67 (02) :270-275
[7]   Annual zoledronate increases bone density in highly active Antiretroviral therapy-treated human immunodeficiency virus-infected men: A randomized controlled trial [J].
Bolland, Mark J. ;
Grey, Andrew B. ;
Horne, Anne M. ;
Briggs, Simon E. ;
Thomas, Mark G. ;
Ellis-Pegler, Rod B. ;
Woodhouse, Andrew F. ;
Gamble, Greg D. ;
Reid, Ian R. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (04) :1283-1288
[8]   Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review [J].
Brown, Todd T. ;
Qaqish, Roula B. .
AIDS, 2006, 20 (17) :2165-2174
[9]   Loss of Bone Mineral Density After Antiretroviral Therapy Initiation, Independent of Antiretroviral Regimen [J].
Brown, Todd T. ;
McComsey, Grace A. ;
King, Martin S. ;
Qaqish, Roula B. ;
Bernstein, Barry M. ;
da Silva, Barbara A. .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2009, 51 (05) :554-561
[10]   Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy [J].
Bruera, D ;
Luna, N ;
David, DO ;
Bergoglio, LA ;
Zamudio, J .
AIDS, 2003, 17 (13) :1917-1923